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INA B16 bearing

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Soft matter DNA nanoparticles hybridized with CpG motifs .

 B16-OVA tumor growth in the spleen was greatly inhibited by INA treatment compared to other treatments (Figs. 6 A and B). During the treatment INA in the B16-OVA tumor bearing mice, the body weight was not considerably decreased, indicates the INA is not toxic in the mouse in vivo (Figure S8).

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Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg .

 immunotherapy, animals bearing B16-IDO or B16-WT tumors were treated with antibodies to CTLA-4, PD-1, or a combination of both. While combination therapy led to 60% long-term animal survival in the B16-WT tumor-bearing mice, B16-IDO tumors were completely resistant to therapy (Figure 2C). Altogether,

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